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Formation of dihydrate from carbamazepine anhydrate in aqueous conditions

1984; Elsevier BV; Volume: 20; Issue: 3 Linguagem: Inglês

10.1016/0378-5173(84)90177-7

1873-3476

Ensio Laine, Virpi Tuominen, Pekko Ilvessalo, P Kahela,

Crystallization and Solubility Studies

According to our observations, carbamazepine dihydrate crystals grow by the whisker mechanism (or mechanisms). The habit, the dimensions of the crystals and their rapid growth indicate this. Also the strong orientation in the X-ray diffractogram is in harmony with the whisker theory. The whisker growth explains also the rapid transition from the anhydrous form to the dihydrate one in water. Dihydrate whiskers which are loosely in the solution as well as ones fastened to the surface of the anhydrous mother crystal has been observed. The oriented crystal structure of carbamazepine dihydrate may be at least one important factor in the growth mechanism of carbamazepine dihydrate whiskers.