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Calcitonin gene polymorphismCALCA-624 (T/C) and ovarian cancer

2005; Wiley; Volume: 46; Issue: 1 Linguagem: Inglês

10.1002/em.20134

1098-2280

Marc T. Goodman, Robert E. Ferrell, Katharine McDuffie, Pamela J. Thompson, Lynne R. Wilkens, Abigail W. Bushley, Ko-Hui Tung, Michael E. Carney, Roberta B. Ness,

Hormonal Regulation and Hypertension

Environmental and Molecular MutagenesisVolume 46, Issue 1 p. 53-58 Research Article Calcitonin gene polymorphism CALCA-624 (T/C) and ovarian cancer† Marc T. Goodman, Corresponding Author Marc T. Goodman [email protected] Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiEtiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813. Phone (808) 586-2987; Fax: (808) 586-2982Search for more papers by this authorRobert Ferrell, Robert Ferrell University of Pittsburgh Graduate School of Public Health, Pittsburgh, PennsylvaniaSearch for more papers by this authorKatharine McDuffie, Katharine McDuffie Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorPamela J. Thompson, Pamela J. Thompson Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorLynne R. Wilkens, Lynne R. Wilkens Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorAbigail W. Bushley, Abigail W. Bushley Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorKo-Hui Tung, Ko-Hui Tung Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorMichael E. Carney, Michael E. Carney Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorRoberta B. Ness, Roberta B. Ness University of Pittsburgh Graduate School of Public Health, Pittsburgh, PennsylvaniaSearch for more papers by this author Marc T. Goodman, Corresponding Author Marc T. Goodman [email protected] Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiEtiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813. Phone (808) 586-2987; Fax: (808) 586-2982Search for more papers by this authorRobert Ferrell, Robert Ferrell University of Pittsburgh Graduate School of Public Health, Pittsburgh, PennsylvaniaSearch for more papers by this authorKatharine McDuffie, Katharine McDuffie Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorPamela J. Thompson, Pamela J. Thompson Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorLynne R. Wilkens, Lynne R. Wilkens Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorAbigail W. Bushley, Abigail W. Bushley Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorKo-Hui Tung, Ko-Hui Tung Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorMichael E. Carney, Michael E. Carney Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HawaiiSearch for more papers by this authorRoberta B. Ness, Roberta B. Ness University of Pittsburgh Graduate School of Public Health, Pittsburgh, PennsylvaniaSearch for more papers by this author First published: 02 May 2005 https://doi.org/10.1002/em.20134Citations: 14 † The contents of this paper are solely the responsibility of the authors and does not necessarily represent the official views or policies of the National Cancer Institute AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract In a previous analysis, we reported an inverse association of dietary calcium intake with the risk of ovarian cancer (Goodman et al. 2002. Am J Epidemiol 156:148–57). The CALCA gene codes for calcitonin, an important regulator of bone calcium metabolism. Data from a population-based case-control study conducted in Hawaii were used to examine the hypothesis that a T → C transition 624 base pairs upstream (−624) of the translation initiation codon of the CALCA gene influences the risk of ovarian malignancy. A structured interview was conducted for 182 histologically confirmed ovarian cancer cases and 219 controls. Blood specimens were collected from the subjects' at their homes. A significant negative trend (P for trend: 0.02) in the odds ratios (ORs) was found with increasing intake of calcium. Women with any CALCA C allele were at nonsignificantly higher risk of ovarian cancer (OR: 1.5, 95% CI: 0.9–2.3) compared to women with the TT genotype and the risk increased with the number of C alleles (P for trend: 0.05). When further analyzed within ethnic subgroups, a significant positive association was found among Japanese for CALCA CT (OR: 2.3, 95% CI: 1.0–5.3) and CALCA CC (OR: 7.2, 95% CI: 1.1–46.0) compared with Japanese women who were homozygous for the T allele. The trend in risk associated with the C allele was most significant among women who had used oral contraceptives (P for trend: 0.05), had been pregnant (P for trend: 0.04), and had nonmucinous histological types of ovarian cancer (P for trend: 0.02). However, the association of ovarian cancer risk with the CALCA genotype was not significantly modified by any of the dietary, nondietary, or clinical variables included in this study. 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