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Blood Group Antigen Expression in Frozen Sections of Presenting Bladder Cancer: 3‐year Prospective Follow‐up of Prognostic Value

1989; Wiley; Volume: 63; Issue: 2 Linguagem: Inglês

10.1111/j.1464-410x.1989.tb05158.x

1365-2176

P D Abel, Susan J. Thorpe, G. Williams,

Glycosylation and Glycoproteins Research

Summary— Blood group antigen (BGA) expression was studied on frozen sections from the initial, presenting, transitional cell bladder cancers of 73 patients. Clinical follow‐up was prospective and, after 3 years, 59 patients were available for assessment. Of 32 tumours that retained substantial BGA (BGA+ and BGA±), 11 progressed. Of 27 tumours with < 5%or undetectable BGA expression (BGA‐), 14 did not progress. Of 24 pTa tumours, 17 had substantial BGA expression and 7 were BGA‐; 5 patients progressed, 4 substantially BGA positive and 1 BGA‐, all to category pT1; 15 tumours were category pT1, 7 substantially BGA positive and 8 BGA‐; 7 patients progressed, 1 substantially BGA positive and 6 BGA‐, all of whom died from bladder cancer; 20 were pT2 or deeper, 8 substantially BGA positive and 12 BGA‐; 12 patients progressed, 6 substantially BGA positive and 6 BGA‐, all of whom died from bladder cancer. Despite improved understanding of the biochemistry and techniques of detection of BGA, these results preclude the use of BGA determination as a guide to prognosis in individual transitional cell carcinoma, whether used alone or in combination with pT category.