Human β-migrating very low density lipoprotein induces foam cell formation in human mesangial cells
1997; Elsevier BV; Volume: 135; Issue: 2 Linguagem: Inglês
10.1016/s0021-9150(97)00166-4
ISSN1879-1484
AutoresYoshichika Anami, Shozo Kobori, Masakazu Sakai, Masaya Kasho, Takeshi Nishikawa, Toshihiro Yano, Hirofumi Matsuda, Takeshi Matsumura, Toru Takemura, Motoaki Shichiri,
Tópico(s)Diabetes Treatment and Management
ResumoTo elucidate the mechanism of foam cell formation in the mesangial region of a kidney observed in a familial type III hyperlipoproteinemic patient presenting with diabetes mellitus and nephrotic syndrome, we have examined, in the present study, the effect of human β-VLDL (apo E2/E2) on foam cell formation in human mesangial cells, since an increase in β-VLDL is a characteristic feature of this patient. Human β-VLDL (apo E2/E2) induced foam cell formation in human mesangial cells. The binding of [125I]LDL to human mesangial cells was inhibited completely by both LDL and β-VLDL. On the other hand, the binding of [125I]β-VLDL was completely inhibited by β-VLDL, but partially by LDL. The LDL receptor, but not the VLDL receptor was down-regulated by accumulation of cholesteryl esters. These results suggest that human β-VLDL (apo E2/E2)-induced foam cell formation in mesangial cells is mediated through both the LDL receptor pathway and the β-VLDL specific pathway, in which the VLDL receptor is one of the candidates.
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