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Stability of vancomycin in plastic syringes measured by high–performance liquid chromatography

1995; Wiley; Volume: 20; Issue: 6 Linguagem: Inglês

10.1111/j.1365-2710.1995.tb00705.x

1365-2710

Marsha Wood, Reidar Lund, M. Beavan,

Antibiotics Pharmacokinetics and Efficacy

Journal of Clinical Pharmacy and TherapeuticsVolume 20, Issue 6 p. 319-325 Stability of vancomycin in plastic syringes measured by high–performance liquid chromatography M. J. Wood BSc, MPhil, Corresponding Author M. J. Wood BSc, MPhil Pharmacy Department, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, U.K.Department of Pharmacy, Salford Royal Hospital NHS Trust, Hope Hospital, Eccles Old Road, Salford, Manchester M6 8HD, U.K.Search for more papers by this authorR. Lund BSc, MSc, R. Lund BSc, MSc Pharmacy Department, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, U.K.Search for more papers by this authorM. Beavan HNC (Pharm. Sci.), BA, M. Beavan HNC (Pharm. Sci.), BA Pharmacy Department, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, U.K.Search for more papers by this author M. J. Wood BSc, MPhil, Corresponding Author M. J. Wood BSc, MPhil Pharmacy Department, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, U.K.Department of Pharmacy, Salford Royal Hospital NHS Trust, Hope Hospital, Eccles Old Road, Salford, Manchester M6 8HD, U.K.Search for more papers by this authorR. Lund BSc, MSc, R. Lund BSc, MSc Pharmacy Department, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, U.K.Search for more papers by this authorM. Beavan HNC (Pharm. Sci.), BA, M. Beavan HNC (Pharm. Sci.), BA Pharmacy Department, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Edgbaston, Birmingham, U.K.Search for more papers by this author First published: December 1995 https://doi.org/10.1111/j.1365-2710.1995.tb00705.xCitations: 14AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL SUMMARY The shelf–life of vancomycin in infusion fluids was studied using high–performance liquid chromatographic (HPLC) methods. Vancomycin was stable (loss in potency less than 10%) for 47 days and 29 days, respectively, when dissolved in waterfor–injections BP at 25°C and stored in plastic syringes (Becton Dickinson Plastipak (three–piece) and B. Braun Medical Injekt (two–piece)). In sodium chloride solution (0 9%; pH 5 4) it was stable for 62 and 34 days, while in dextrose solution (5%; pH 4 2) it was stable for 55 and 33 days, respectively, at the same temperature. At 4°C vancomycin was stable in all three infusion fluids and both types of syringe for at least 84 days. REFERENCES 1 Perkins HR. (1982) Vancomycin and related antibiotics. Pharmacology and Therapeutics, 16, 181– 197. 2 Bint AJ, Finch RG, Gokal R, et al. (1987) Diagnosis and management of peritonitis in continuous ambulatory peritoneal dialysis–Report of a Working Party of the British Society for Antimicrobial Chemotherapy. Lancet, 1, 845– 848. 3 White LO, Edwards R, Holt HA, Lovering AM, Finch RG, Reeves DS. 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(1983) Vancomycin: structure and transformation to CDP–I. Journal of the American Chemical Society, 105, 6915– 6922. 14 Harris CM, Kopecka H, Harris TM. (1985) The stabilization of vancomycin by peptidoglycan analogues. Journal of Antibiotics, XXXVIII, 51– 57. 15 Marshall FJ. (1965) Structure studies on vancomycin. Journal of Medicinal Chemistry, 8, 18– 22. Citing Literature Volume20, Issue6December 1995Pages 319-325 ReferencesRelatedInformation