Primary pulmonary hyalinizing clear cell carcinoma of bronchial submucosal gland origin
2014; Elsevier BV; Volume: 46; Issue: 3 Linguagem: Inglês
10.1016/j.humpath.2014.11.010
ISSN1532-8392
AutoresJoaquín J. García, Long Jin, Shawn B. Jackson, Brandon T. Larsen, Jean E. Lewis, William R. Sukov, Anja C. Roden,
Tópico(s)Oral and Maxillofacial Pathology
ResumoHyalinizing clear cell carcinoma (HCCC) has only been described in salivary glands of the head and neck. We report a 38-year-old man with a 2.6-cm lung tumor that was growing in a peribronchial location and had morphologic features of HCCC. The tumor cells expressed cytokeratin 7 and keratin AE1/AE3, and the vast majority of tumor cells marked also with p63 and p40. They were negative for cytokeratin 20, S-100, smooth muscle actin, napsin A, and thyroid transcription factor-1. Fluorescence in situ hybridization revealed Ewing Sarcoma Breakpoint Region 1 (EWSR1) rearrangement, and reverse-transcription polymerase chain reaction confirmed the presence of the EWSR1-Activating Transcription Factor 1 (ATF1) fusion transcript, which was subsequently sequenced. The morphologic, immunophenotypic, cytogenetic, and molecular findings together with the patient's history and location of the tumor support a diagnosis of primary pulmonary HCCC of bronchial submucosal gland origin. It is our understanding that this is the first report of HCCC arising as a primary tumor outside the head and neck region.
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