Immunization of pigs against infection with Schistosoma japonicum using ultraviolet-attenuated cercariae
1993; Cambridge University Press; Volume: 106; Issue: 5 Linguagem: Inglês
10.1017/s0031182000076745
ISSN1469-8161
AutoresY. E. Shi, Chang-Fu Jiang, Jiajun Han, Y.-L. Li, A. Ruppel,
Tópico(s)Helminth infection and control
ResumoSince pigs are important in the zoonotic transmission of schistosomiasis japonica in China, a veterinary vaccine might contribute to the control of the disease in humans. Pigs were immunized with three doses each of 10,000 cercariae of Schistosoma japonicum attenuated with ultraviolet light (400 microWatt.min/cm2). The experiment was performed with portable irradiation equipment in a rural area of the Hubei Province (P.R. China). A challenge infection of 1,000 untreated cercariae was given 2.5 or 6 months after the last immunization, and age-matched naive pigs were challenged as a control. Immunized pigs developed about 90% resistance against the challenge. The liver egg load of these animals was reduced by over 90%. Less than 0.01% of the immunizing cercariae developed to adult parasites and the vaccination had no apparent adverse influence on the pigs' health.
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