β-Catenin destruction complex: insights and questions from a structural perspective
2006; Springer Nature; Volume: 25; Issue: 57 Linguagem: Inglês
10.1038/sj.onc.1210055
ISSN1476-5594
Autores Tópico(s)Cancer-related gene regulation
ResumoAt the heart of the canonical Wnt signaling pathway is the β-catenin destruction complex, which functions in the absence of Wnt signaling to keep the cytosolic and nuclear levels of β-catenin very low by promoting the phosphorylation and ubiquitination of β-catenin. Structural studies, combined with other experimental approaches, have begun to provide important insights into the mechanism of the destruction complex. We suggest a working model for the destruction complex based on the existing structural and experimental data, and focus on the questions that this model and other studies have raised about the function of the complex in both the normal and Wnt-inhibited states.
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