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Anti-Tumor-Promoting Activities of Afromosin and Soyasaponin I Isolated from Wistaria brachybotrys

1992; American Chemical Society; Volume: 55; Issue: 12 Linguagem: Inglês

10.1021/np50090a011

1520-6025

Takao Konoshima, Midori Kokumai, Mutsuo Kozuka, Harukuni Tokuda, H. Nishino, Akio Iwahima,

Plant-Derived Bioactive Compounds

Afromosin [1] and soyasaponin I [2] isolated from Wistaria brachybotrys exhibited remarkable inhibitory effects on mouse skin tumor promotion, and afromosin also exhibited a significant inhibitory effect on pulmonary tumor promotion. The combined effects of these compounds on the two-stage skin carcinogenesis were also examined, and it was concluded that the combination of 1 with 2 enhanced the inhibitory effect.