Portal de Periódicos da CAPES

Biosynthesis of DNA by Isolated Mitochondria: Incorporation of Thymidine Triphosphate-2-C 14

1967; American Association for the Advancement of Science; Volume: 155; Issue: 3758 Linguagem: Inglês

10.1126/science.155.3758.91

1095-9203

Peter G. Parsons, Melvin V. Simpson,

DNA Repair Mechanisms

Thymidine triphosphate-2-C(14) and other deoxynucleoside triphosphates are incorporated into the DNA of isolated mitochondria from rat liver cells. The reaction is partially dependent on the other deoxynucleoside triphosphates and proceeds in the virtual absence of bacteria. The product has the properties of mitochondrial rather than nuclear DNA, and end-group studies indicate labeling of the interior of the molecule.