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Erratum: Corrigendum: Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

2004; Nature Portfolio; Volume: 11; Issue: 12 Linguagem: Inglês

10.1038/nsmb1204-1253a

1545-9993

Michal Harel, Amir Aharoni, Leonid Gaidukov, Boris Brumshtein, Olga Khersonsky, Ran Meged, Hay Dvir, Raimond B. G. Ravelli, Andrew A. McCarthy, Lilly Toker, Israel Silman, Joel L. Sussman, Dan S. Tawfik,

Biochemical Acid Research Studies

Nat. Struct. Mol. Biol. 11, 412–419 (2004). Some of the enzymatic activity data for paraoxonase (PON1) reported in this article were biased by two factors. First, the gene encoding the H115Q mutant contained an additional H177R mutation introduced during PCR amplification. Although His177 is far from the active site and the H177R mutant by itself is 70% active compared to the wild-type PON1, the combined H115Q H177R mutant is almost completely inactive.