Portal de Periódicos da CAPES

Functional expression of CD28 on T cell antigen receptor γ/δ‐bearing T lymphocytes

1989; Wiley; Volume: 19; Issue: 1 Linguagem: Inglês

10.1002/eji.1830190129

1521-4141

Roberto Testi, Lewis L. Lanier,

Immune Cell Function and Interaction

Abstract T lymphocytes express a T cell antigen receptor (TcR) complex composed of either an TcR α/β or TcR γ/δ heterodimer in noncovalent association with the CD3 glycoproteins. CD28, a 44‐kDa disulfide‐linked homodimer, is present on the surface of the majority of TcR α/β‐bearing T lymphocytes. Monoclonal antibodies (mAb) directed against CD28 potentiate activation signals delivered through the CD3/TcR α/β complex. Herein, we demonstrate that CD28 is expressed on ∼40%–60% of TcR γ/δ‐bearing T lymphocytes in most donors. Anti‐CD28 mAb substantially augmented proliferative signals delivered through the TcR γ/δ, demonstrating the presence of functional CD28 molecules on TcR γ/δ‐bearing T lymphocytes. The majority of TcR γ/δ thymocytes also expressed CD28.