EXOPHTHALMIC GOITER AND MYXEDEMA: REPORT OF A CASE*
1928; Oxford University Press; Volume: 12; Issue: 1 Linguagem: Inglês
10.1210/endo-12-1-55
ISSN1945-7170
Autores Tópico(s)Thyroid Disorders and Treatments
ResumoThe characteristic phenomena of exophthalmic goiter are probably brought about because of the production and delivery to the tissues of an abnormal agent from the thyroid gland. This agent is usually associated with an excess of the normal thyroid secretion, but that it must be so is not essential to the hypothesis that in exophthalmic goiter two products are elaborated by the thyroid gland, nor is it consistent with theoretical or practical considerations of thyroid function and disease. There is abundant evidence that the thyroid gland may produce amounts of secretion sufficient to hold the basal metabolic rate at a normal level and still be associated with the phenomena of exophthalmic goiter, presumably because of an abnormal secretion. It is theoretically possible to have the abnormal thyroid secretion so limited in amount that, when controlled with compound solution of iodine (Lugol's solution) the patient shows frank evidence of myxedema; and in the same patient to find the phenomena of exophthalmic goiter when the patient is not taking iodine. This condition is exemplified in the following case:
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