Leukaemia of novel gastrointestinal T-lymphocyte population infected with HTLV-I
1991; Elsevier BV; Volume: 337; Issue: 8733 Linguagem: Inglês
10.1016/0140-6736(91)90737-a
ISSN1474-547X
AutoresToshio Hattori, Norio Asou, Hitoshi Suzushima, Kiyoshi Takatsuki, Keiko Tanaka, Katsusuke Naito, H Natori, K Oizumi,
Tópico(s)Animal Disease Management and Epidemiology
ResumoIn a 72-year-old man with watery diarrhoea and leukocytosis the proliferation of abnormal cells was studied in specimens obtained by endoscopic biopsy of the gastrointestinal tract. Flow cytometry of leukaemia cells revealed a monoclonal expansion of "double-negative" (CD4-, CD8-) cells bearing T-cell receptor (TCR) alpha beta products. Southern blotting confirmed monoclonal integration of HTLV-I. A novel T-cell subset of double-negative TCR alpha beta cells in the gastrointestinal tract in adult man may be a target for HTLV-I infection.
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