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Immunophenotypic Comparison of Salivary Gland Oncocytoma and Metastatic Renal Cell Carcinoma

2005; Wiley; Volume: 115; Issue: 6 Linguagem: Inglês

10.1097/01.mlg.0000163497.61332.77

1531-4995

John A. Ozolek, Sheldon Bastacky, Eugene N. Myers, Jennifer L. Hunt,

Oral and Maxillofacial Pathology

The LaryngoscopeVolume 115, Issue 6 p. 1097-1100 Article Immunophenotypic Comparison of Salivary Gland Oncocytoma and Metastatic Renal Cell Carcinoma† John A. Ozolek MD, John A. Ozolek MD Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.Search for more papers by this authorSheldon I. Bastacky MD, Sheldon I. Bastacky MD Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.Search for more papers by this authorEugene N. Myers MD, Eugene N. Myers MD Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.Search for more papers by this authorJennifer L. Hunt MD, Corresponding Author Jennifer L. Hunt MD [email protected] Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.Dr. Jennifer L. Hunt, Director, Molecular Anatomic Pathology, Assistant Professor of Head and Neck/Endocrine Pathology and Otolaryngology, PUH A610.2., Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh PA 15213, U.S.A.Search for more papers by this author John A. Ozolek MD, John A. Ozolek MD Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.Search for more papers by this authorSheldon I. Bastacky MD, Sheldon I. Bastacky MD Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.Search for more papers by this authorEugene N. Myers MD, Eugene N. Myers MD Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.Search for more papers by this authorJennifer L. Hunt MD, Corresponding Author Jennifer L. Hunt MD [email protected] Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.Dr. Jennifer L. Hunt, Director, Molecular Anatomic Pathology, Assistant Professor of Head and Neck/Endocrine Pathology and Otolaryngology, PUH A610.2., Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh PA 15213, U.S.A.Search for more papers by this author First published: 03 January 2009 https://doi.org/10.1097/01.MLG.0000163497.61332.77Citations: 35 † This study was presented at the United States and Canadian Academy of Pathology meeting in Vancouver, BC, March 2004. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Objectives/Hypothesis: The differential diagnosis of oncocytic neoplasms of salivary glands includes both primary and metastatic tumors, one of which is renal cell carcinoma. This study compared immunohistochemical staining characteristics of oncocytomas arising from salivary gland to metastatic renal cell carcinoma using a panel of markers. Study Design: Immunohistochemistry for cytokeratin 7 (CK7), cytokeratin 20 (CK20), epithelial membrane antigen (EMA), vimentin, CD10, and renal cell carcinoma marker (RCC) was performed on 10 oncocytomas and compared with ten metastatic renal cell carcinomas. Results: There were overlapping histologic findings in the oncocytomas and metastatic renal cell carcinomas, with oncocytomas displaying clear cell changes in 2 of 10 cases. CK7 was positive in 9 of 10 oncocytomas and CK20 in 8 of 10 (7/10 stained for both), and vimentin was only weakly positive in 4 of 10 oncocytomas. All oncocytomas were EMA positive, with membranous staining, and all were negative for CD10 and RCC. Metastatic renal cell carcinoma was strongly positive for vimentin, EMA, and CD10 in most cases. RCC and CK7 were variably positive in metastatic renal cell carcinomas (4/10), and only 1 of 10 showed weak staining with CK20. 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