Synthesis and Properties of Segmented Poly(urethane-urea)s Containing Phosphorylcholine Moiety in the Side-Chain
2008; Springer Nature; Volume: 40; Issue: 12 Linguagem: Inglês
10.1295/polymj.pj2008158
ISSN1349-0540
AutoresYu Nagase, Satoru Nakajima, Masataka Oku, Yasuhiko Iwasaki, Kazuhíko Ishihara,
Tópico(s)Polymer Surface Interaction Studies
ResumoIn order to improve the biocompatibility of segmented polyurethane which has been widely used as a biomedical material, the synthesis of segmented poly(urethane-urea) containing phosphorylcholine (PC) moiety was carried out by using aromatic diamine monomer with PC unit. The obtained poly(urethane-urea)s were soluble in aprotic polar solvents such as NMP, DMSO and DMF, but insoluble in water, alcohol and acetone. In addition, it was confirmed from the results of blood contacting experiments that the polymer exhibited the excellent biocompatibility, even though the PC content was around 15 wt. %, which would be due to the surface structure derived from PC side chain. From the results of stress-strain measurements, poly(urethane-urea) films exhibited the elastic properties, which were almost as same as those of segmented polyurethane. On the other hand, the gas permeability of the poly(urethane-urea) film, which consisted of the high permeable siloxane soft segment, slightly increased as compared with polyurethane film consisting the similar backbone component.
Referência(s)