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Fine Mapping of Five Human Skeletal Muscle Genes: Alpha-Tropomyosin, Beta-Tropomyosin, Troponin-I Slow-Twitch, Troponin-I Fast-Twitch, and Troponin-C Fast

1997; Elsevier BV; Volume: 230; Issue: 2 Linguagem: Inglês

10.1006/bbrc.1996.5958

1090-2104

Natascia Tiso, Luca Rampoldi, Alberto Pallavicini, Rosanna Zimbello, D. Pandolfo, Giorgio Valle, Gerolamo Lanfranchi, Gian Antonio Danieli,

Cardiomyopathy and Myosin Studies

In this paper the chromosomal localization of the human skeletal muscle genes Troponin-I slow-twitch (TNNI1), Troponin-I fast-twitch (TNNI2), and Troponin-C fast (TNNC2) and the refinement of the position for alpha-Tropomyosin (TPM1) and beta-Tropomyosin (TPM2) are reported. By radiation hybrid mapping, TPM1 was assigned to chromosome 15q22.1, TPM2 to chromosome 9p13.2-p13.1, TNNI1 to chromosome 1q31.3, TNNI2 to chromosome 11p15.5, and TNNC2 to chromosome 20q12-q13.11. The genomic distribution of these genes is discussed, with particular emphasis on the cluster organization of the Troponin genes.