Portal de Periódicos da CAPES

Oral and maxillofacial manifestations of Gardner’s syndrome associated with growth hormone deficiency: Case report and literature review

2007; Elsevier BV; Volume: 103; Issue: 6 Linguagem: Inglês

10.1016/j.tripleo.2007.01.013

1528-395X

Luca Ramaglia, Fabio Morgese, Mariagiovanna Filippella, Annamaria Colao,

Soft tissue tumor case studies

Gardner’s syndrome (GS) is a hereditary disorder inherited as autosomal dominant with complete penetrance and variable expression. GS is a variant of familial adenomatous polyposis characterized by extracolonic manifestations including osteomas, dental anomalies, and epidermoid cysts. The association between GS and endocrine abnormalities has been well documented but a direct pituitary involvement has never been reported. We present a case of oral and maxillofacial manifestations in an adult patient affected by GS associated with growth hormone deficiency, a hitherto unreported association. The possible pathogenic mechanisms are discussed. Gardner’s syndrome (GS) is a hereditary disorder inherited as autosomal dominant with complete penetrance and variable expression. GS is a variant of familial adenomatous polyposis characterized by extracolonic manifestations including osteomas, dental anomalies, and epidermoid cysts. The association between GS and endocrine abnormalities has been well documented but a direct pituitary involvement has never been reported. We present a case of oral and maxillofacial manifestations in an adult patient affected by GS associated with growth hormone deficiency, a hitherto unreported association. The possible pathogenic mechanisms are discussed.