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Reversed-Phase High-Performance Liquid Chromatography Combined with On-Line UV Diode Array, FT Infrared, and 1 H Nuclear Magnetic Resonance Spectroscopy and Time-of-Flight Mass Spectrometry: Application to a Mixture of Nonsteroidal Antiinflammatory Drugs

2000; American Chemical Society; Volume: 72; Issue: 16 Linguagem: Inglês

10.1021/ac000204y

1520-6882

Dave Louden, Alan Handley, S. Taylor, Eva M. Lenz, Steve Miller, Ian D. Wilson, Ashley Sage,

Advanced Chemical Sensor Technologies

A prototype multiply hyphenated system has been applied to the analysis of a mixture of nonsteroidal antiinflammatory drugs separated by reversed-phase HPLC. Characterization of the model NSAIDs was achieved via a combination of diode array UV, 1H NMR, FT-IR spectroscopy, and time-of-flight mass spectrometry. This combination of spectrometers allowed the collection of UV, 1H NMR, IR, and mass spectra together with atomic composition data enabling almost complete structural characterization to be performed.