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Idiopathic Asymptomatic Thrombocytopenia in Cavalier King Charles Spaniels Is an Autosomal Recessive Trait

2002; Wiley; Volume: 16; Issue: 2 Linguagem: Inglês

10.1892/0891-6640(2002)016 2.3.co;2

1939-1676

Henrik D. Pedersen, Jens Häggström, Lisbeth H. Olsen, K. C. Christensen, Anna Selin, Malene L. Burmeister, Heidi Larsen,

Blood properties and coagulation

Journal of Veterinary Internal MedicineVolume 16, Issue 2 p. 169-173 Open Access Idiopathic Asymptomatic Thrombocytopenia in Cavalier King Charles Spaniels Is an Autosomal Recessive Trait Henrik D. Pedersen, Corresponding Author Henrik D. Pedersen Departments of Anatomy and Physiology The Royal Veterinary and Agricultural University, Frederiksberg, Denmark Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, DK-1870 Frederiksberg C, Denmark; e-mail: hdp@kvl.dk.Search for more papers by this authorJens Häggström, Jens Häggström Department of Physiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.Search for more papers by this authorLisbeth H. Olsen, Lisbeth H. Olsen Departments of Anatomy and Physiology The Royal Veterinary and Agricultural University, Frederiksberg, DenmarkSearch for more papers by this authorKnud Christensen, Knud Christensen Departments of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Frederiksberg, DenmarkSearch for more papers by this authorAnna Selin, Anna Selin Department of Physiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.Search for more papers by this authorMalene L. Burmeister, Malene L. Burmeister Departments of Anatomy and Physiology The Royal Veterinary and Agricultural University, Frederiksberg, DenmarkSearch for more papers by this authorHeidi Larsen, Heidi Larsen Departments of Anatomy and Physiology The Royal Veterinary and Agricultural University, Frederiksberg, DenmarkSearch for more papers by this author Henrik D. Pedersen, Corresponding Author Henrik D. Pedersen Departments of Anatomy and Physiology The Royal Veterinary and Agricultural University, Frederiksberg, Denmark Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, 7 Groennegaardsvej, DK-1870 Frederiksberg C, Denmark; e-mail: hdp@kvl.dk.Search for more papers by this authorJens Häggström, Jens Häggström Department of Physiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.Search for more papers by this authorLisbeth H. Olsen, Lisbeth H. Olsen Departments of Anatomy and Physiology The Royal Veterinary and Agricultural University, Frederiksberg, DenmarkSearch for more papers by this authorKnud Christensen, Knud Christensen Departments of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Frederiksberg, DenmarkSearch for more papers by this authorAnna Selin, Anna Selin Department of Physiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.Search for more papers by this authorMalene L. Burmeister, Malene L. Burmeister Departments of Anatomy and Physiology The Royal Veterinary and Agricultural University, Frederiksberg, DenmarkSearch for more papers by this authorHeidi Larsen, Heidi Larsen Departments of Anatomy and Physiology The Royal Veterinary and Agricultural University, Frederiksberg, DenmarkSearch for more papers by this author First published: 28 June 2008 https://doi.org/10.1111/j.1939-1676.2002.tb02350.xCitations: 47AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Cavalier King Charles Spaniels (CKCS) often have idiopathic asymptomatic thrombocytopenia. In affected dogs, the thrombocytes often are large, and it has been speculated that the condition could be an inherited macrothrombocytopenia. The aim of this study was to examine the inheritance of idiopathic, asymptomatic thrombocytopenia in CKCS. Sixteen families (both parents and ≥3 offspring) of privately owned CKCS were included. There were 105 clinically healthy dogs (50 from Denmark and 55 from Sweden): 81 offspring and 26 parents (2 dogs had both roles). Because autoanalyzers have difficulty counting large platelets, the platelets were counted manually, with a counting chamber. Platelet counts were not influenced by age, gender, or heart murmur status. Thrombocytopenia (≤100,000 platelets/|μL) was found in 46% of the parents. The pedigrees indicated that thrombocytopenia segregated as an autosomal recessive trait and that 100,000 platelets/|μL was appropriate as a lower limit of normal. Affected offspring were found in all families, showing that all of the included parents were at least carriers. Therefore, the expected segregation ratios (which were in good accordance with the observed ones) were 1:0, 1:1, and 1:3 for the 3 crosses: affected X affected, normal X affected, and normal X normal. Within a given cross, the mean parental platelet count had no influence on the platelet counts of the offspring. We conclude that idiopathic, asymptomatic thrombocytopenia in CKCS is inherited in an autosomal recessive manner. The condition most likely constitutes an inherited macrothrombocytopenia in dogs. Citing Literature Volume16, Issue2March 2002Pages 169-173 ReferencesRelatedInformation