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Terpene synthases are widely distributed in bacteria

2014; National Academy of Sciences; Volume: 112; Issue: 3 Linguagem: Inglês

10.1073/pnas.1422108112

1091-6490

Yuuki Yamada, Tomohisa Kuzuyama, Mamoru Komatsu, Kazuo Shin‐ya, Satoshi Ōmura, David E. Cane, Haruo Ikeda,

Microbial Metabolism and Applications

Significance Terpenes are generally considered to be plant or fungal metabolites, although a small number of odoriferous terpenes of bacterial origin have been known for many years. Recently, extensive bacterial genome sequencing and bioinformatic analysis of deduced bacterial proteins using a profile based on a hidden Markov model have revealed 262 distinct predicted terpene synthases. Although many of these presumptive terpene synthase genes seem to be silent in their parent microorganisms, controlled expression of these genes in an engineered heterologous Streptomyces host has made it possible to identify the biochemical function of the encoded terpene synthases. Genes encoding such terpene synthases have been shown to be widely distributed in bacteria and represent a fertile source for discovery of new natural products.