INHIBITION OF HUMAN GRANULOSA CELL PROGESTERONE SECRETION BY A GONADOTROPIN-RELEASING HORMONE AGONIST
1982; Oxford University Press; Volume: 54; Issue: 5 Linguagem: Inglês
10.1210/jcem-54-5-1078
ISSN1945-7197
AutoresRichard W. Tureck, Luigi Mastroianni, Luis Blasco, Jerome F. Strauss,
Tópico(s)Reproductive Physiology in Livestock
ResumoA gonadotropin-releasing hormone (Gn-RH) agonist was found to inhibit the secretion of progesterone by cultured human granulosa cells in a dose-dependent manner. Significant inhibition was observed at agonist concentrations of 10-9M. A Gn-RH antagonist had no marked effect upon progestin secretion, but it prevented the inhibitory effects of the Gn-RH agonist. We conclude that Gn-RH-like substances can directly affect human granulosa cell function.
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