In vivo effects of phenytoin and phenobarbital on GABA receptors in rat cerebral cortex and cerebellum
1984; Elsevier BV; Volume: 46; Issue: 3 Linguagem: Inglês
10.1016/0304-3940(84)90108-3
ISSN1872-7972
AutoresYoshihisa Tatsuoka, Yuzuru Kato, Kazuhide Yoshida, Hiroo Imura,
Tópico(s)Ion channel regulation and function
ResumoThe in vivo effects of anticonvulsants on specific binding of [3H]GABA in the rat brain were examined in male Wistar rats. Acute treatment with phenobarbital increased specific [3H]GABA binding in the cerebral cortex, whereas repeated treatment with phenobarbital failed to change [3H]GABA binding. [3H]GABA binding in the cerebellum was not influenced by phenobarbital administration. Acute treatment with phenytoin produced no change in [3H]GABA binding, whereas repeated treatment with phenytoin caused a significant increase in [3H]GABA binding in the cerebellum, but not in the cerebral cortex. The effects of these anticonvulsants may be due, at least in part, to GABA receptor-mediated mechanisms.
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