Adrenergic agonists suppress the proliferation of microglia through β2-adrenergic receptor
1998; Elsevier BV; Volume: 242; Issue: 1 Linguagem: Inglês
10.1016/s0304-3940(98)00003-2
ISSN1872-7972
AutoresHiroko Fujita, Junya Tanaka, Nobuji Maeda, Masahiro Sakanaka,
Tópico(s)Receptor Mechanisms and Signaling
ResumoThe effects of several cyclic adenosine monophosphate (cAMP)-elevating agents on the proliferation of cultured rat microglia were investigated by immunocytochemical staining with an antibody against proliferating cell nuclear antigen (PCNA). Epinephrine, isoproterenol, forskolin and 8Br-cAMP suppressed the microglial proliferation. A β2-selective agonist terbutaline but not a β1-selective agonist dobutamine mimicked the effect of the above cAMP-elevating agents. Furthermore, a non-selective β-receptor antagonist oxprenolol and a β2-selective antagonist acebutalol, but not a β1-selective antagonist butoxamine, counteracted the suppressive effects of the β-agonists on microglial proliferation. These findings suggest that the β-agonists suppress the proliferation of microglia by elevating intracellular cAMP level through an action on β2-adrenergic receptor.
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