Novel, selective mechanism-based inhibitors of the herpes proteases
1996; Elsevier BV; Volume: 6; Issue: 20 Linguagem: Inglês
10.1016/0960-894x(96)00456-8
ISSN1464-3405
AutoresIvan L. Pinto, Andrew B. West, Christine Debouck, Anthony G. DiLella, Joselina Gorniak, Kevin O’Donnell, Daniel J. O’Shannessy, Arunbai Patel, Richard L. Jarvest,
Tópico(s)Synthesis and Biological Evaluation
ResumoA novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by forming covalent complexes are described. Two new families of inhibitor, the spirocyclopropyl oxazolones and the benzylidine N-sulphonyloxyimidazolones, have been shown to be submicromolar inhibitors of HSV-2 and HCMV proteases which are selective relative to a panel of standard serine proteases.
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