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Triterpenoid saponins of the Caryophyllaceae and Illecebraceae family

2010; Elsevier BV; Volume: 4; Issue: 2 Linguagem: Inglês

10.1016/j.phytol.2010.08.003

1876-7486

Stefan Böttger, Matthias F. Melzig,

Plant biochemistry and biosynthesis

The closely related plant families of Caryophyllaceae and Illecebraceae are reviewed for their saponins. An overview with special attention on the contained sapogenins and their linkage of sugar moieties are provided. Gypsogenin, gypsogenic acid and quillaic acid turned out to be widely spread in the family of Caryophyllaceae. Gypsogenin is found in 46% of the examined species. The occurrence of gypsogenin is 1.5-fold higher than that of gypsogenic acid or quillaic acid, which occur with the same frequency. The genus Gypsophila L. of the family of Caryophyllaceae has the highest accumulation of gypsogenin. 75% of the examined species contain gypsogenin. It appears 3-fold more often than gypsogenic acid or quillaic acid in this genus. In contrast, all examined species of the family of Illecebraceae lack of gypsogenin. Since certain bisdesmosidic gypsogenin-based saponins of Gypsophila paniculata L. recently showed the ability to drastically amplify the toxicity of cellular membrane-impermeable type I ribosome-inactivating proteins (type I RIPs), the analysis reveals other possible natural sources for further testing.