The Role of Hepcidin in Iron Metabolism
2009; Karger Publishers; Volume: 122; Issue: 2-3 Linguagem: Inglês
10.1159/000243791
ISSN1421-9662
Autores Tópico(s)Erythropoietin and Anemia Treatment
ResumoHepcidin is the central regulator of systemic iron homeostasis. Dysregulation of hepcidin production results in a variety of iron disorders. Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic kidney disease and iron-refractory iron deficiency anemia. Diagnostic and therapeutic applications of this new knowledge are beginning to emerge. Dr. Ernest Beutler played a significant role in advancing our understanding of the function of hepcidin. This review is dedicated to his memory.
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