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MULTIVARIATE ANALYSIS OF THE PROGNOSTIC FACTORS OF PRIMARY SUPERFICIAL BLADDER CANCER

2000; Lippincott Williams & Wilkins; Volume: 163; Issue: 1 Linguagem: Inglês

10.1016/s0022-5347(05)67975-x

1527-3792

F. Millán‐Rodríguez, G. Chéchile-Toniolo, J. SALVADOR-BAYARRI, Joan Palou, Juan Carlos de Vicente,

Cancer Immunotherapy and Biomarkers

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jan 2000MULTIVARIATE ANALYSIS OF THE PROGNOSTIC FACTORS OF PRIMARY SUPERFICIAL BLADDER CANCER F. MILLÁN-RODRÍGUEZ, G. CHÉCHILE-TONIOLO, J. SALVADOR-BAYARRI, J. PALOU, and J. VICENTE-RODRÍGUEZ F. MILLÁN-RODRÍGUEZF. MILLÁN-RODRÍGUEZ , G. CHÉCHILE-TONIOLOG. CHÉCHILE-TONIOLO , J. SALVADOR-BAYARRIJ. SALVADOR-BAYARRI , J. PALOUJ. PALOU , and J. VICENTE-RODRÍGUEZJ. VICENTE-RODRÍGUEZ View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67975-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluate the prognostic factors of recurrence, progression and disease specific mortality in patients with primary superficial Ta and T1 transitional cell carcinoma of the bladder. Materials and Methods: We studied a cohort of 1,529 patients with primary superficial transitional cell carcinoma of the bladder treated with transurethral resection and random bladder biopsies. Mean followup was 4.2 years. Statistical analysis was performed using the Kaplan-Meier method and multivariate analysis was done with the Cox proportional hazards model with stepwise forward selection. All p values were 2-sided, with odds ratios and 95% confidence intervals. Results: Multiple tumors (odds ratio 2), tumor greater than 3 cm. (1.65) and carcinoma in situ (1.6) increased, whereas intravesical bacillus Calmette-Guerin (BCG) instillations (0.39) decreased the risk of recurrence. Grade 3 disease (odds ratio 19.9), multiple tumors (1.9), tumor greater than 3 cm. (1.7) and carcinoma in situ (2.1) increased, whereas BCG (0.3) decreased the risk of progression. Grade 3 disease (odds ratio 14) and carcinoma in situ (odds ratio 3) increased the risk of disease specific mortality. Conclusions: Neither tumor stage nor dysplasia influenced tumor evolution. Multiple tumors, tumor greater than 3 cm. and intravesical BCG instillations were risk factors of recurrence and progression. Carcinoma in situ influenced recurrence, progression and disease specific mortality. Finally, the main predictor of progression and mortality was grade 3 disease. References 1 : Prognostic factors in superficial bladder tumors. A study of the European Organization for Research on Treatment of Cancer: Genitourinary Tract Cancer Cooperative Group. J Urol1983; 129: 730. Link, Google Scholar 2 : Prognostic factors for recurrence and followup policies in the treatment of superficial bladder cancer: report from the British Medical Research Council Subgroup on Superficial Bladder Cancer (Urological Cancer Working Party). J Urol1989; 142: 284. Link, Google Scholar 3 : Random bladder biopsies and the risk of recurrent superficial bladder cancer: a prospective study in 1026 patients. 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Google Scholar From the Department of Urology, Fundació Puigvert, Barcelona, Spain© 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKamat A, Witjes J, Brausi M, Soloway M, Lamm D, Persad R, Buckley R, Böhle A, Colombel M and Palou J (2014) Defining and Treating the Spectrum of Intermediate Risk Nonmuscle Invasive Bladder CancerJournal of Urology, VOL. 192, NO. 2, (305-315), Online publication date: 1-Aug-2014.Miñana B, Cózar J, Palou J, Unda Urzaiz M, Medina-Lopez R, Subirá Ríos J, de la Rosa-Kehrmann F, Chantada-Abal V, Lozano F, Ribal M, Rodríguez Fernández E, Castiñeiras Fernández J, Concepción Masip T, Requena-Tapia M, Moreno-Sierra J, Hevia M, Gómez Rodríguez A, Martínez-Ballesteros C, Ramos M, Amón Sesmero J, Pizá Reus P, Bohorquez Barrientos A, Rioja Sanz C, Gomez-Pascual J, Hidalgo Zabala E, Parra Escobar J and Serrano O (2013) Bladder Cancer in Spain 2011: Population Based StudyJournal of Urology, VOL. 191, NO. 2, (323-328), Online publication date: 1-Feb-2014.Lamm D, Persad R, Brausi M, Buckley R, Witjes J, Palou J, Böhle A, Kamat A, Colombel M and Soloway M (2013) Defining Progression in Nonmuscle Invasive Bladder Cancer: It is Time for a New, Standard DefinitionJournal of Urology, VOL. 191, NO. 1, (20-27), Online publication date: 1-Jan-2014.Tanaka N, Kikuchi E, Matsumoto K, Miyajima A, Nakagawa K and Oya M (2010) Frequency of Tumor Recurrence: A Strong Predictor of Stage Progression in Initially Diagnosed Nonmuscle Invasive Bladder CancerJournal of Urology, VOL. 185, NO. 2, (450-455), Online publication date: 1-Feb-2011.Alkhateeb S, Van Rhijn B, Finelli A, van der Kwast T, Evans A, Hanna S, Vajpeyi R, Fleshner N, Jewett M and Zlotta A (2010) Nonprimary pT1 Nonmuscle Invasive Bladder Cancer Treated With Bacillus Calmette-Guerin is Associated With Higher Risk of Progression Compared to Primary T1 TumorsJournal of Urology, VOL. 184, NO. 1, (81-86), Online publication date: 1-Jul-2010.Di̇vri̇k R, Şahi̇n A, Altok M, Ünlü N and Zorlu F (2007) The Frequency of Hydronephrosis at Initial Diagnosis and its Effect on Recurrence and Progression in Patients With Superficial Bladder CancerJournal of Urology, VOL. 178, NO. 3, (802-806), Online publication date: 1-Sep-2007.Takahashi T, Hagisawa S, Yoshikawa K, Tezuka F, Kaku M and Ohyama C (2018) Predictive Value of N-Acetylglucosaminyltransferase-V for Superficial Bladder Cancer RecurrenceJournal of Urology, VOL. 175, NO. 1, (90-93), Online publication date: 1-Jan-2006.PALOU J, RODRÍGUEZ-RUBIO F, HUGUET J, SEGARRA J, RIBAL M, ALCARAZ A and VILLAVICENCIO H (2018) MULTIVARIATE ANALYSIS OF CLINICAL PARAMETERS OF SYNCHRONOUS PRIMARY SUPERFICIAL BLADDER CANCER AND UPPER URINARY TRACT TUMORJournal of Urology, VOL. 174, NO. 3, (859-861), Online publication date: 1-Sep-2005.MULLERAD M, RUSSO P, GOLIJANIN D, CHEN H, TSAI H, DONAT S, BOCHNER B, HERR H, SHEINFELD J, SOGANI P, KATTAN M and DALBAGNI G (2018) BLADDER CANCER AS A PROGNOSTIC FACTOR FOR UPPER TRACT TRANSITIONAL CELL CARCINOMAJournal of Urology, VOL. 172, NO. 6 Part 1, (2177-2181), Online publication date: 1-Dec-2004.LEE C, SMITH C, HALL J, WATERS W and BIERMANN J (2018) Bladder Cancer Facts: Accuracy of Information on the InternetJournal of Urology, VOL. 170, NO. 5, (1756-1760), Online publication date: 1-Nov-2003.GRIMM M, STEINHOFF C, SIMON X, SPIEGELHALDER P, ACKERMANN R and VÖGELI T (2018) Effect of Routine Repeat Transurethral Resection for Superficial Bladder Cancer: A Long-term Observational StudyJournal of Urology, VOL. 170, NO. 2, (433-437), Online publication date: 1-Aug-2003.BÖHLE A, JOCHAM D and BOCK P (2018) Intravesical Bacillus Calmette-Guerin Versus Mitomycin C For Superficial Bladder Cancer: A Formal Meta-Analysis of Comparative Studies on Recurrence and ToxicityJournal of Urology, VOL. 169, NO. 1, (90-95), Online publication date: 1-Jan-2003.PALOU J, LAGUNA P, MILLÁN-RODRÍGUEZ F, HALL R, SALVADOR-BAYARRI J and VICENTE-RODRÍGUEZ J (2018) CONTROL GROUP AND MAINTENANCE TREATMENT WITH BACILLUS CALMETTE-GUERIN FOR CARCINOMA IN SITU AND/OR HIGH GRADE BLADDER TUMORSJournal of Urology, VOL. 165, NO. 5, (1488-1491), Online publication date: 1-May-2001. 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Volume 163Issue 1January 2000Page: 73-78 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.Keywordsdisease progressionrecurrencesurvivalbladder neoplasmsMetricsAuthor Information F. MILLÁN-RODRÍGUEZ More articles by this author G. CHÉCHILE-TONIOLO More articles by this author J. SALVADOR-BAYARRI More articles by this author J. PALOU More articles by this author J. VICENTE-RODRÍGUEZ More articles by this author Expand All Advertisement PDF downloadLoading ...