In vitro Biological Activity of Salvia leriifolia Benth Essential Oil Relevant to the Treatment of Alzheimer's Disease
2009; Japan Oil Chemists' Society; Volume: 58; Issue: 8 Linguagem: Inglês
10.5650/jos.58.443
ISSN1347-3352
AutoresMonica Rosa Loizzo, Francesco Menichini, Rosa Tundis, Marco Bonesi, Filomena Conforti, Farsad Nadjafi, Giancarlo Statti, Natale G. Frega, Francesco Menichini,
Tópico(s)Computational Drug Discovery Methods
ResumoIn this study the chemical composition, cholinesterase inhibitory property and anti-inflammatory activity of S. leriifolia Benth. essential oil was evaluated for the first time. GC and GC-MS analysis revealed the presence of camphor (10.5%), 1,8-cineole (8.6%), camphene (6.2%) and alpha-pinene (4.7%) as main constituents. S. leriifolia oil exhibited a promising antioxidant activity by DPPH assay with an IC(50) 2.26 microL/mL. Interesting cholinesterase inhibitory activity was also found with IC(50) values of 0.32 and 0.29 microL/mL for acetylcholinesterase (AChE) and butyrrylcholinesterase (BChE), respectively. Moreover, this oil inhibited LPS-induced NO production with an IC(50) value of 165 microg/mL. The absence of cytotoxicity at 1000 microg/mL was evaluated by MTT assay in 142BR cells.
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