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Renin-aldosterone response to dexamethasone in glucocorticoid-suppressible hyperaldosteronism is altered by coexistent renal artery stenosis.

1993; Oxford University Press; Volume: 77; Issue: 3 Linguagem: Inglês

10.1210/jcem.77.3.8396580

1945-7197

Michael Stowasser, Richard D. Gordon, S. A. Klemm, Terry J. Tunny,

Renin-Angiotensin System Studies

The responses of renin, aldosterone, and blood pressure to ACTH suppression with dexamethasone in a 61-yr-old man with glucocorticoid-suppressible hyperaldosteronism were modified by coexistent atheromatous renal artery stenosis (RAS). The apparent responsiveness of aldosterone to angiotensin-II resulting from RAS has implications for the regulation of steroidogenesis in this condition. After successful surgical correction of the RAS, the response changed and resembled that seen in two younger males (one his son) with uncomplicated glucocorticoid-suppressible hyperaldosteronism.