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Platelets, Petechiae, and Preservation of the Vascular Wall

2008; Massachusetts Medical Society; Volume: 359; Issue: 12 Linguagem: Inglês

10.1056/nejmra0800887

1533-4406

Ralph L. Nachman, Shahin Rafii,

Apelin-related biomedical research

This review concerns functional contacts between platelets and endothelial cells, with emphasis on the maintenance of vascular integrity by proangiogenic cytokines and growth factors released by platelets. These molecules bind to receptors on the surface of endothelial cells, thereby stabilizing the vascular-endothelium cadherin complex.