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Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT

2010; Springer Nature; Volume: 102; Issue: 8 Linguagem: Inglês

10.1038/sj.bjc.6605635

1532-1827

Despina Handolias, Anne Hamilton, Renato Salemi, Angela Tan, Kate Moodie, Lucille Kerr, Alexander Dobrovic, Grant A. McArthur,

Cutaneous Melanoma Detection and Management

Mutations in KIT are more frequent in specific melanoma subtypes, and response to KIT inhibition is likely to depend on the identified mutation. A total of 32 patients with metastatic acral or mucosal melanoma were screened for mutations in KIT exons 11, 13 and 17. KIT mutations were found in 38% of mucosal and in 6% of acral melanomas. Three patients were treated with imatinib and one with sorafenib. All four patients responded to treatment, but three have since progressed within the brain. The observed clinical responses support further investigation of KIT inhibitors in metastatic melanoma, selected according to KIT mutation status.