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Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese

2005; Springer Nature; Volume: 6; Issue: 4 Linguagem: Inglês

10.1038/sj.gene.6364189

1476-5470

Gloria Hoi Wan Tso, Wai‐Ki Ip, Wai Po Chong, Cheuk Ming Tam, Aks Chiang, YL Lau,

Immune Response and Inflammation

Interferon gamma (IFN-γ) and interleukin 10 (IL-10) are believed to play opposing roles in host immunity against mycobacterial infection. IFN-γ activates macrophages, while IL-10 downregulates the expression of T helper type 1 cytokines, MHC class II antigens and costimulatory molecules on macrophages. Associations of IFN-γ −179 (G/T), +874 (A/T), +875 miscrosatellite CA repeats and +4766 (C/T), and IL-10 −1082 (A/G), −819 (C/T) and −592 (C/A) with tuberculosis (TB) were investigated in 385 HIV-negative patients and 451 controls in a Hong Kong Chinese population. The frequency of a low IFN-γ-producing +874 A/A genotype was significantly over-represented in the patient group (P<0.001, OR=3.79, 95% CI=1.93–7.45). We identified 10 alleles in the IFN-γ CA repeats and observed a significant difference in allele frequency distribution between patients and controls (P<0.001). By grouping alleles into 12 and non-12 CA repeats, the non-12/non-12 genotype yielded a similar significant result (P<0.001, OR=4.56, 95% CI=2.21–9.43) as observed in +874 A/A genotype. Weak associations of the IL-10 GCC/− genotype (P=0.04) and the low IFN-γ-producing A/A genotype (P=0.06) with TB relapse/extrapulmonary cases were found. This study suggests the possible role of interferon gamma in TB susceptibility.