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Structural proteomics of dengue virus

2008; Elsevier BV; Volume: 11; Issue: 4 Linguagem: Inglês

10.1016/j.mib.2008.06.004

1879-0364

Rushika Perera, Richard Kühn,

Viral Infections and Outbreaks Research

In this paper, we discuss recent advances in our knowledge of the dengue virus life cycle based on new structural data of the virus and its proteins. Specifically, we focus on the structure of the pre-membrane protein, prM and its role in virus assembly, the first full-length structure of a multi-domain dengue virus replication protein, NS3, and the recently solved structures of NS5 methyltransferase and polymerase domains. These structures provide a basis for describing function and predicting putative host interactions.