Produção Nacional
Revisado por pares
Mouriri elliptica: Validation of gastroprotective, healing and anti-Helicobacter pylori effects
2009; Elsevier BV; Volume: 123; Issue: 3 Linguagem: Inglês
10.1016/j.jep.2009.03.040
ISSN1872-7573
AutoresFábio Cruz Moleiro, Márcio Adriano Andréo, Raquel de Cássia dos Santos, Thiago de Mello Moraes, Clenilson Martins Rodrigues, Camila Bernardes de Andrade Carli, Flávia Cristine Mascia Lopes, Cláudia Helena Pellizzon, Iracilda Zeppone Carlos, Taís Maria Bauab, Wagner Vilegas, Clélia Akiko Hiruma-Lima,
Tópico(s)Phytochemical Studies and Bioactivities
ResumoMouriri elliptica Martius (Melastomataceae) is species reputed in folk medicine to heal gastric ulcer and gastritis. Methanolic extract (ME) and ethyl acetate fraction (EAF) from leaves of Mouriri elliptica were evaluated for their gastroprotective, healing, immunological, toxicological and anti-Helicobacter pylori activities. The gastroprotective action of ME and EAF was evaluated in rodent experimental models and to elucidate mechanisms of action, the antisecretory action, involvements of NO, SH, PGE2, anti-Helicobacter pylori action of ME was evaluated. We also used immunohistochemical (PCNA and COX-2) and immunomodulatory (murine peritoneal macrophages) assays to evaluate Mouriri elliptica effects. ME present gastroprotective action without antisecretory effect. Otherwise, ME showed anti-Helicobacter pylori action (MIC = 0.025 μg/mL) and was able to inhibit NO production by macrophages. This species also accelerate the healing of ulcerated gastric mucosa by stimulating proliferation factors (PCNA), COX-2 and maintained basal PGE2 level independent action of NSAID in gastric mucosa. The phytochemical investigation showed that this species possesses phenolic acid derivatives, acylglycoflavonoids and condensed tannins which probably influenced their pharmacological action. All these results suggest the efficacy and safety of Mouriri elliptica in combating and healing gastric ulcer.
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