A population of nicotinic receptors is associated with thalamocortical afferents in the adult rat: Laminal and areal analysis
1997; Wiley; Volume: 380; Issue: 2 Linguagem: Inglês
10.1002/(sici)1096-9861(19970407)380
ISSN1096-9861
AutoresNatalie Lavine, Melanie Reuben, Paul B. S. Clarke,
Tópico(s)Photoreceptor and optogenetics research
ResumoJournal of Comparative NeurologyVolume 380, Issue 2 p. 175-190 A population of nicotinic receptors is associated with thalamocortical afferents in the adult rat: Laminal and areal analysis Natalie Lavine, Natalie Lavine Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada H3G 1Y6Search for more papers by this authorMelanie Reuben, Melanie Reuben Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada H3G 1Y6Search for more papers by this authorPaul B.S. Clarke, Corresponding Author Paul B.S. Clarke pclarke@pharma.mcgill.Ca Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada H3G 1Y6Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Room 1325, Montréal, Québec, Canada H3G 1Y6.Search for more papers by this author Natalie Lavine, Natalie Lavine Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada H3G 1Y6Search for more papers by this authorMelanie Reuben, Melanie Reuben Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada H3G 1Y6Search for more papers by this authorPaul B.S. Clarke, Corresponding Author Paul B.S. Clarke pclarke@pharma.mcgill.Ca Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada H3G 1Y6Department of Pharmacology and Therapeutics, McGill University, 3655 Drummond Street, Room 1325, Montréal, Québec, Canada H3G 1Y6.Search for more papers by this author First published: 06 December 1998 https://doi.org/10.1002/(SICI)1096-9861(19970407)380:2 3.0.CO;2-0Citations: 49AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract In the adult rat brain, a prominent population of nicotinic cholinoceptors binds 3H-nicotine with nanomolar affinity. These receptors are abundant in most thalamic nuclei and in neocortical layers 3/4, which receive a major thalamic input. To test whether cortical nicotinic receptors are associated with thalamocortical afferents, unilateral excitotoxic (N-methyl-D-aspartate) lesions were made in one of four thalamic nuclear groups (anterior, ventral, medial geniculate, or dorsal lateral geniculate) or in temporal cortex. After 1 or 4 weeks of survival, cortical 3H-nicotine binding was quantified via autoradiography. Thalamic lesions resulted in a partial loss of 3H-nicotine binding in ipsilateral cerebral cortex. In each thalamic lesion group, the greatest decrease (35–45%) occurred within the cortical layers and area (i.e., cingulate, parietal, temporal, or occipital cortex) receiving the densest thalamocortical innervation. Binding of 3H-nicotine was also reduced within the thalamus local to the lesion, particularly at the longer survival time. Saturation analysis, performed in frontoparietal cortical tissue homogenates following ventral thalamic lesions, revealed a significant (34%) reduction in receptor density but not affinity. Direct excitotoxic lesions of the neocortex (temporal cortex) tended to preserve 3H-nicotine binding in layers 3/4, despite local neuronal loss. These results, taken with other published findings, suggest that some nicotinic cholinoceptors in adult rat cerebral cortex are located on thalamocortical terminals. This organizing principle appears to apply not only to sensory and motor relay projections but also to association nuclei that project to allocortical areas. These receptors may provide a local mechanism for nicotinic cholinergic modulation of thalamocortical input. J. Comp. Neurol. 380:175–190, 1997. © 1997 Wiley-Liss, Inc. Citing Literature Volume380, Issue27 April 1997Pages 175-190 RelatedInformation
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