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In Vitro Activity of Telavancin against Gram-Positive Clinical Isolates Recently Obtained in Europe

2007; American Society for Microbiology; Volume: 51; Issue: 9 Linguagem: Inglês

10.1128/aac.00100-07

1098-6596

Wim Jansen, A. Verel, J. Verhoef, D. Milatović,

Bacterial Identification and Susceptibility Testing

The in vitro activity of telavancin was tested against 620 gram-positive isolates. For staphylococci, MICs at which 50 and 90% of isolates were inhibited (MIC(50) and MIC(90)) were both 0.25 microg/ml, irrespective of methicillin resistance. MIC(50) and MIC(90) were 0.25 and 0.5 microg/ml for vancomycin-susceptible enterococci and 1 and 2 microg/ml for vancomycin-resistant enterococci, respectively. Streptococcus pneumoniae, group A and B beta-hemolytic streptococci, and viridans streptococci were inhibited by < or =0.12 microg/ml.