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Molecular Light Switches for Calf Thymus DNA Based on Three Ru(II) Bipyridyl Complexes with Variations of Heteroatoms

2007; American Chemical Society; Volume: 111; Issue: 44 Linguagem: Inglês

10.1021/jp075194k

1932-7455

Mei‐Jiao Han, Zhiming Duan, Qiang Hao, Shuai-Zhi Zheng, Ke‐Zhi Wang,

Magnetism in coordination complexes

The three Ru(II) complexes of [Ru(bpy)2(bipp)](ClO4)2 (1), [Ru(bpy)2(bopp)](ClO4)2 (2), and [Ru(bpy)2(btpp)](ClO4)2 (3) (where bpy = 2,2'-bipyridine, bipp = 2-benzimidazoyl-pyrazino[2,3-f] [1,10]phenanthroline, bopp = 2-benzoxazolyl-pyrazino[2,3-f] [1,10]phenanthroline, and btpp = 2-benzthiazolyl-pyrazino[2,3-f] [1,10]phenanthroline) with variations in heteroatoms of NH (1), O(2), and S(3), have been synthesized and characterized. These complexes have been shown to act as promising calf thymus DNA intercalators and a new class of DNA light switches for the DNA, as evidenced by UV−visible and luminescence titrations, steady-state emission quenching by [Fe(CN)6]4-, DNA competitive binding with ethidium bromide, reverse salt titrations, viscosity measurements, and DNA melting experiments.