Portal de Periódicos da CAPES

Valve Disease Associated with Ergot Alkaloid Use: Echocardiographic and Pathologic Correlations

1992; American College of Physicians; Volume: 117; Issue: 1 Linguagem: Inglês

10.7326/0003-4819-117-1-50

1539-3704

Margaret M. Redfield, W. J. Nicholson, William D. Edwards, A. Jamil Tajik,

Plant and fungal interactions

Brief Reports1 July 1992Valve Disease Associated with Ergot Alkaloid Use: Echocardiographic and Pathologic CorrelationsMargaret M. Redfield, MD, Walter J. Nicholson, MD, William D. Edwards, MD, A. Jamil Tajik, MDMargaret M. Redfield, MD, Walter J. Nicholson, MD, William D. Edwards, MD, A. Jamil Tajik, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-1-50 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptErgot alkaloid preparations such as ergotamine (Cafergot, Sandoz, East Hanover, New Jersey) and methysergide (Sansert, Sandoz) are used to treat migraine headache. Characteristic histologic changes are seen in patients with methysergide-induced valvular disease (primarily mitral and aortic regurgitation) (1, 2). Recently, ergotamine-induced valvular disease was documented pathologically (3). We report the echocardiographic and pathologic features of five patients with valvular disease associated with long-term ingestion of ergot alkaloids.PatientsCase HistoriesAll patients were using ergot alkaloid preparations for treatment of headache. Patients were initially identified because gross pathologic findings were thought to be unusually severe for rheumatic disease. The...References1. BanaMacNealLeCompteShahGraham DPPYJ. Cardiac murmurs and endocardial fibrosis associated with methysergide therapy. Am Heart J. 1974;88:640-55. CrossrefMedlineGoogle Scholar2. Misch K. Development of heart valve lesions during methysergide therapy. Br Med J. 1974;2:365-6. CrossrefMedlineGoogle Scholar3. HauckEdwardsDanielsonMullanyBresnahan AWGCD. Mitral and aortic valve disease associated with ergotamine therapy for migraine: report of two cases and review of literature. Arch Pathol Lab Med. 1990;114:62-4. MedlineGoogle Scholar4. MunroeAllenCox DPA. Mitral regurgitation occurring during methysergide (Sansert) therapy. Can Med Assoc J. 1969;101:62-5. MedlineGoogle Scholar5. MasonBillinghamFriedman JMJ. Methysergide-induced heart disease: a case of multivalvular and myocardial fibrosis. Circulation. 1977;56:889-90. CrossrefMedlineGoogle Scholar6. Spierings E. Cardiac murmurs indicative of aortic valve disease with chronic and excessive intake of ergotamine. Headache. 1988;28:278-9. CrossrefMedlineGoogle Scholar7. SeilerJenzerKàcl KHJ. Verlauf eines Falles von Ergotismus mit Femoralarterienverschlüssen und Mitralinsuffizienz. Vasa. 1973;2:366-71. MedlineGoogle Scholar8. Graham J. Cardiac and pulmonary fibrosis during methysergide therapy for headache. Am J Med Sci. 1967;254:1-12. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Mayo Clinic and Mayo Foundation, Rochester, Minnesota; and Cardiac Diagnostics Associates, York, Pennsylvania. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMitral Regurgitation in Patients Undergoing Noncardiac SurgeryMonitoring patients receiving dopamine agonist therapy for hyperprolactinaemiaPostoperative Management of Patients After Transcatheter Mitral Valve Procedures5-HT2B Receptor on Macrophages: What for?Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter MechanismsValvular Heart Disease: Pathological Anatomy and PathogenesisRheumatic Heart DiseaseMechanotransduction Mechanisms in Mitral Valve Physiology and Disease PathogenesisDrug-Induced Fibrosing LesionsProspective, long-term study of the effect of cabergoline on valvular status in patients with prolactinoma and idiopathic hyperprolactinemiaDrugs That May Cause or Exacerbate Heart FailureThe safety of treatments for prolactinomasValvular Heart DiseaseCarcinoid heart disease: Diagnosis and managementValvular Heart Disease in Patients with Prolactinomas on Cabergoline TreatmentCabergoline Use for Pituitary Tumors and Valvular DisordersInduction of Valvular Heart Disease by Pharmacological InterventionsCardiovascular Toxicity of Noncardiovascular DrugsValvular Heart Disease Associated with Long-term Treatment by Methysergide: a Case ReportSafety of long-term treatment with cabergoline on cardiac valve disease in patients with prolactinomasCardiac Valve Involvement in Systemic Diseases: A ReviewScientific Opinion on Ergot alkaloids in food and feedNative Cardiac Valve PathologyCardiovascular SystemSupplemental Studies for Cardiovascular Risk Assessment in Safety Pharmacology: A Critical OverviewRegression of Cardiac Valvulopathy Related to Ergot-Derived Dopamine AgonistsSerotonin receptors and heart valve disease—It was meant 2BThe risk of valvular regurgitation in patients with Parkinson's disease treated with dopamine receptor agonistsAortic valve disease and treatment: The need for naturally engineered solutionsMitral StenosisEvaluation of Tricuspid Regurgitation by Two-Dimensional and Doppler EchocardiographyDrug-induced Valvulopathy: An UpdateProlactinomasMitral ValveReport and Recommendations of the Workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced CardiotoxicityDrug-induced fibrotic valvular heart diseaseRole of Serotoninergic Pathways in Drug-Induced Valvular Heart Disease and Diagnostic Features by EchocardiographyCyproheptadine prevents pergolide-induced valvulopathy in rats: an echocardiographic and histopathological studyRisk of valvular heart disease associated with the use of dopamine agonists in Parkinson's disease: a systematic reviewRight-Sided Valve DiseaseValvular heart disease in patients with Parkinson's disease treated with pergolide, levodopa or bothValvular heart disease and the use of cabergoline for the treatment of prolactinoma2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart DiseaseIncreased Prevalence of Tricuspid Regurgitation in Patients with Prolactinomas Chronically Treated with Cabergoline2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart DiseaseAortic Valve Calcification and Mild Tricuspid Regurgitation But No Clinical Heart Disease after 8 Years of Dopamine Agonist Therapy for ProlactinomaThe frequency of cardiac valvular regurgitation in Parkinson's diseasePergolide Associated Cardiac Valvulopathy Based on Ontario Administrative DataThe safety of dopamine agonists in the treatment of Parkinson's diseaseCardiac Valvular Pathology: Comparative Pathology and Animal Models of Acquired Cardiac Valvular DiseasesRole of dopamine agonists in Parkinson's disease: an updateDopamine agonists and valvular heart disease in patients with Parkinson's disease: evidence and mysteryValvular Heart Disease and the Use of Dopamine Agonists for Parkinson's DiseaseCardiovascular Complications of Obesity and the Metabolic SyndromeValvular Heart Disease: Anatomic AbnormalitiesEchocardiography in the Evaluation of Cardiac Disease Resulting from Endocrinopathies, Renal Disease, Obesity, and Nutritional DeficienciesImpact of Weight-Loss Medications on the Cardiovascular SystemMethysergide-Induced Valvular Heart Disease: A Report of 2 CasesPathology of inflammatory native valvular heart diseaseACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart DiseaseACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart DiseaseAdvances in the Treatment of ProlactinomasObesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight LossCardiac Valvulopathy Associated with Pergolide UseLésions acquises de la valve tricuspideSafety of Drug Therapies Used for Weight Loss and Treatment of ObesityCabergoline-Related Severe Restrictive Mitral RegurgitationTOXIC CARDIOPATHIESValvular Heart Disease in Patients Taking PergolideValvulopathies sous pergolide : revue critique de la littérature et conduite à tenir en pratiqueAgonism at 5-HT2B receptors is not a class effect of the ergolinesValvular Heart Disease Associated With ErgotamineValvulopatía por uso de ergotaminaInsuffisance aortique pure de l'adulteSevere multivalvular heart disease: A new complication of the ergot derivative dopamine agonistsValvulopathies sous pergolide : la saga des fibroses dues aux dérivés de l'ergot de seigle continue !The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and effluxSuccessful Repair of Aortic and Mitral Incompetence Induced by Methylsergide Maleate: Confirmation by Intraoperative Transesophageal EchocardiographyValvular Heart Disease in Patients Taking PergolideAppetite suppressants and valvular heart diseaseEndocardial Myxomatous Change in Harlan Sprague-Dawley Rats (Hsd:S—D) and CD-1 Mice: Its Microscopic Resemblance to Drug-Induced Valvulopathy in HumansDiet medications and valvular hearl disease: the current evidenceThe safety of triptans in the treatment of patients with migraineSurgical Pathology of Carcinoid Heart Disease: A Study of 139 Valves From 75 Patients Spanning 20 YearsFen-Phen Valve Disease: A Real Entity?Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugsEchocardiographic Assessment of Mitral RegurgitationAssociation between selective serotonin-reuptake inhibitor therapy and heart valve regurgitationThe use of animal models in expression pharmacogenomic analysesGuías de práctica clínica de la Sociedad Española de Cardiología en valvulopatíasRegurgitación valvular causada por fármacos anorexígenosEpidemics of vascular toxicity and pulmonary hypertension: what can be learned?Echocardiographic prevalence of mitral and/or aortic regurgitation in patients exposed to either fenfluramine-phentermine combination or to dexfenfluramineObesity drugs and the heartThe Fen-Phen Controversy: Is Regression Another Piece of the Puzzle?Low prevalence of valvular heart disease in 226 phentermine-fenfluramine protocol subjects prospectively followed for up to 30 monthsHistologic Changes in Three Explanted Native Cardiac Valves Following Use of FenfluraminesSerial Echocardiographic and Clinical Evaluation of Valvular Regurgitation Before, During, and After Treatment with Fenfluramine or Dexfenfluramine and Mazindol or PhentermineValve replacement for appetite suppressant–induced valvular heart diseaseHerzTransesophageal Echocardiography with Pathological Correlation in Severe Valvular Disease Associated with Fenfluramine-PhentermineACC/AHA guidelines for the management of patients with valvular heart diseaseHypertension artérielle pulmonaire et valvulopathies induites par les fenfluramines? Hypothèses ou certitudes? Mythe ou réalité?The Prevalence of Cardiac Valvular Insufficiency Assessed by Transthoracic Echocardiography in Obese Patients Treated with Appetite-Suppressant DrugsPatterns of drug-induced cardiovascular pathology in the beagle dog: relevance for humansValve disease associated with chronic intake of fenfluraminesEndocardial Fibrosis Associated with Fenfluramine–PhentermineAbrupt Discontinuation of Fenfluramine and Dexfenfluramine May Cause Serotonin Withdrawal SyndromeValvular Heart Disease Associated with Fenfluramine–PhentermineMitral regurgitation caused by chronic ergotamine useHeadachesEchocardiography and Systemic DiseasesEvaluation of surgically excised mitral valves: Revised recommendations based on changing operative procedures in the 1990sNew observations on the etiology of aortic valve disease: A surgical pathologic study of 236 cases from 1990Ergotamine-induced fetal stress: review of side effects of ergot alkaloids during pregnancyDrugs affecting autonomic functions or the extrapyramidal system 1 July 1992Volume 117, Issue 1Page: 50-52KeywordsAlkaloidsDiagnostic techniquesHeadachesHeart diseasesIngestionMigraineValvular diseases Issue Published: 1 July 1992 PDF downloadLoading ...