The effects of vertebral artery injections of an enkephalin analogue, (d-Met2,Pro5)-enkephalinamide, on somatosympathetic reflexes
1985; Elsevier BV; Volume: 53; Issue: 1 Linguagem: Inglês
10.1016/0304-3940(85)90102-8
ISSN1872-7972
AutoresPéter Sándor, Akio Sato, Yuko Sato, Rand S. Swenson,
Tópico(s)Anesthesia and Pain Management
ResumoThe present study was initiated to test the effects of intravertebral arterial injection of an enkephalin analogue (d-Met2,Pro5)-enkephalinamide on somatosympathetic responses to myelinated A afferent and to unmyelinated C afferent stimulation (A- and C-reflex, respectively). In anesthetized cats, 0.5 mg/kg administered directly into the vertebral artery, the artery supplying most of the cat brain stem and upper cervical spinal cord, depressed both the A- and C-reflex (to 66 and 64% of control, respectively) while intravenous or carotid arterial injections did not have any effect on these reflexes. It is suggested that intravertebral arterial administration may be a useful method of restricting the effective sites of delivery of biologically active compounds to areas of the brain supplied by this artery.
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