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The migration of oculomotor neuroblasts across the midline in the chick embryo

1975; Elsevier BV; Volume: 47; Issue: 3 Linguagem: Inglês

10.1016/0014-4886(75)90078-3

1090-2430

Luis Puelles, F. Malagon-Cobos, J.M. Génis-Gálvez,

Developmental Biology and Gene Regulation

A study has been made of oculomotor histogenesis in chick embryos, with special emphasis on the development of the ventromedial subnucleus and the oculomotor commissure. The results corroborate Biondi's report of 1910, which described a group of neuroblasts that detaches itself from the primordial oculomotor column approaches the midline, intercrosses there with the cells coming from the other side, and arrives finally at the contralateral complex, where it differentiates as the ventromedial subnucleus. The migrating neuroblasts draw their axons passively behind them, and thus form the oculomotor commissure. These migrating cells do not seem to be contactguided. The essential difference between alar and basal plate migrating processes is discussed and an hypothetic metabolic guidance mechanism is proposed for the oculomotor migration.