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Chemoattractant Receptor Cross-desensitization

1999; Elsevier BV; Volume: 274; Issue: 10 Linguagem: Inglês

10.1074/jbc.274.10.6027

1083-351X

Hydar Ali, Ricardo M. Richardson, Bodduluri Haribabu, Ralph Snyderman,

Immune Response and Inflammation

Leukocytes participate in host defense by accumulating at local sites in response to inflammatory mediators where they may engulf foreign material and/or release toxic products that can cause substantial tissue damage. Agents of diverse chemical nature (short peptides, proteins, and lipids) have been identified as chemoattractants and stimulate leukocytes through G-protein-coupled receptors (1). Responses of leukocytes can be mediated by chemoattractants alone or modulated by other agents. For example, leukocytes that are attached to adhesion molecules respond to chemoattractants to elicit far greater cytotoxic responses than non-adherent cells.