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Semen Characteristics and Serum and Seminal Plasma Hormones in Drug-Induced Hyperprolactinaemia

1982; Taylor & Francis; Volume: 9; Issue: 4 Linguagem: Inglês

10.3109/01485018208990257

1521-0375

Laurent Diez, José Manuel González de Buitrago,

Ovarian function and disorders

Semen volume, density, motility, viability, and morphology of spermatozoa, and serum and seminal plasma levels of the hormones FSH, LH, prolactin, progesterone, 17-alpha-hydroxyprogesterone, androstenedione, testosterone, dihidrotestosterone, and estradiol 17-beta have been measured in 22 men subjected to experimental hyperprolactinaemia by the simultaneous administration of the antidopaminergic drugs metoclopramide and sulpiride. Hyperprolactinaemia produces a decrease of semen volume and seminal quality. In hyperprolactinaemia, normozoospermic patients had an increase of serum androstenedione. In both normo- and oligozoospermic groups, a decrease of serum testosterone was observed. Hyperprolactinaemia also causes an inhibition of the secretory activity of the accessory sexual glands of the reproductive tract, as well as either a decrease of 17-ketosteroid reductase or an increase of 17-alpha-hydroxysteroid dehydrogenase (enzymes that participate in the androstenedione-testosterone interconversions). This change appears to be more pronounced in individuals with good seminal quality.