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The –590C/T and –34C/T interleukin-4 promoter polymorphisms are not associated with atopic eczema in childhood

2001; Elsevier BV; Volume: 108; Issue: 2 Linguagem: Inglês

10.1067/mai.2001.117180

1097-6825

Kate Elliott, Elizabeth M. Fitzpatrick, David A. Hill, Jenny Brown, Sue K. Adams, Paul Chee, Graeme Stewart, David A. Fulcher, Mimi L.K. Tang, Andrew H. Kemp, Emma King, George Varigos, Melanie Bahlo, Susan Forrest,

Dermatology and Skin Diseases

Susceptibility to the development of asthma and other atopic diseases is known to have a genetic component. To date, several studies have linked chromosome 5q31 to asthma and atopy in human beings. This region harbors a cluster of cytokine and growth factor genes, IL-4 presenting as a prime atopy candidate gene, inasmuch as it plays a pivotal role in the atopy pathway. Our approach was to identify polymorphisms within the promoter regions of IL-4 and test their association with atopic eczema. Polymorphisms were typed in a cohort of 76 small nuclear families and 25 triads with childhood atopic eczema. The genotypes were used to test for linkage in the presence of association with atopic eczema. A new polymorphism, –34C/T, was identified and studied with a known polymorphism, –590C/T. On its own, each polymorphism showed no association with atopic eczema. The 2 polymorphisms were used to generate haplotypes, and a significant result was found for the –590C/–34C haplotype. However, after Bonferroni correction for multiple testing, the association became nonsignificant. Neither polymorphism predisposes to early-onset atopic eczema by itself, but suggestive linkage was found for the –590C/–34C haplotype in this study. (J Allergy Clin Immunol 2001;108:285-7.)