Portal de Periódicos da CAPES

Mycobacterium tuberculosis: a model system for structural genomics

2003; Elsevier BV; Volume: 13; Issue: 6 Linguagem: Inglês

10.1016/j.sbi.2003.10.004

1879-033X

Clare V. Smith, James C. Sacchettini,

Biochemical and Molecular Research

Over the past five years, genomics has had a major impact on Mycobacterium tuberculosis research. With the publication of the sequences of two virulent strains (H37Rv and CDC1551) and three closely related sequences, M. tuberculosis is becoming a model system for proteomics and structural genomics initiatives. Together with the promise of structures of proteins with novel folds, high-resolution structures of drug targets are providing the basis for rational inhibitor design, with the goal of the development of novel anti-tuberculars. In addition, this work is aiding scientists in the quest for an effective vaccine against this persistent pathogen.