Biology of TGF-β in knockout and transgenic mouse models
1997; Elsevier BV; Volume: 51; Issue: 5 Linguagem: Inglês
10.1038/ki.1997.185
ISSN1523-1755
AutoresErwin P. Böttinger, John J. Letterio, Anita B. Roberts,
Tópico(s)Pancreatic and Hepatic Oncology Research
ResumoThis paper reviews the basic biology and biochemistry of the TGF-beta isoforms including their unique serine-threonine receptors and signaling intermediates. Dysregulation of TGF-beta expression and/or receptor/signaling function have been implicated in a wide variety of pathologies. We will discuss mechanisms underlying some of these disease processes as gained from study of transgenic mice in which expression of TGF-beta 1 has either been lost by targeted deletion of its gene, is overexpressed in a tissue-specific manner, or blocked by its latency associated peptide.
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