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BIBTEX RIS

Phenotypic detection of metallo-β-lactamases in Pseudomonas aeruginosa and Acinetobacter baumannii isolated from hospitalized patients in São Luis, State of Maranhão, Brazil

2013; Brazilian Society of Tropical Medicine; Volume: 46; Issue: 4 Linguagem: Inglês

10.1590/0037-8682-1451-2013

ISSN

1678-9849

Autores

Roberto Morais Luz de Carvalho, Sirlei Garcia Marques, Luís Henrique Bastos Gonçalves, Afonso Gomes Abreu, Sílvio Gomes Monteiro, Azizedite Guedes Gonçalves,

Tópico(s)

Bacterial biofilms and quorum sensing

Resumo

Acquired metallo-β-lactamases (MβL) are emerging determinants of resistance in Pseudomonas aeruginosa and Acinetobacter baumannii. The objectives of this study were to phenotypically detect MβL in imipenem-resistant P. aeruginosa and A. baumannii, to investigate the association between MβL-positive strains and hospitals, and to compare the resistance profiles of MβL-producing and non-MβL-producing strains.The approximation disk and combined disk assay methods were used in this study.A total of 18 (38.3%) P. aeruginosa isolates and 1 (5.6%) A. baumannii isolate tested positive for the presence of MβL.These results demonstrate the need for strict surveillance and for the adoption of preventive measures to reduce the spread of infection and potential outbreaks of disease caused by MβL-producing microorganisms.

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