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Automated flow-injection technique for use in dissolution studies of sustained-release formulations: Application to iron(II) formulations

1994; Elsevier BV; Volume: 12; Issue: 5 Linguagem: Inglês

10.1016/0731-7085(93)e0015-f

1873-264X

Constantinos A. Georgiou, Georgia Valsami, Panos Macheras, Michael Α. Koupparis,

Concrete and Cement Materials Research

The application of flow-injection analysis (FIA) to automated dissolution studies of sustained-release formulations is described. The long-term stability of the dissolution—FIA analyser was checked during unattended operation for 42 h. The construction of multiple calibration curves with the so-called electronic dilution FIA procedure was used to extend the linear range of the determination. The computer-controlled FIA system and the principles of associated software are described and applied to dissolution studies of sustained-release formulations of iron (II) using its sensitive reaction with the colour reagent, ferrozine. The extended linear range of the determination is 1–130 ppm iron(II) and the precision (RSD) better than 3% (n = 3).