Chromosomes and survival in multiple myeloma. A banding study of 25 cases
1980; Elsevier BV; Volume: 2; Issue: 3 Linguagem: Inglês
10.1016/0165-4608(80)90031-x
ISSN1873-4456
AutoresPreben Philip, Aage Drivsholm, Niels Ebbe Hansen, Mogens Krogh Jensen, Sven‐Aage Killmann,
Tópico(s)Genomic variations and chromosomal abnormalities
ResumoThe chromosomal findings in 25 cases of multiple myeloma are reported. The chromosomes were directly prepared from bone marrow cells and studied by trypsin-Leishman banding. Abnormal stem lines were found in 16 cases (64%), and were characterized by banding in 12 cases. Twelve cases were hyperdiploid; 11 cases carried marker chromosomes, 50% of which involved chromosome No. 1. Five cases were trisomic for 1q21-1q3. A vulnerable point was located on 3q27 or 28 or 29. The two cases that carried the 14q+ marker chromosome were also the only cases with plasma cells in the peripheral blood. Based on this study and the literature it is suggested that a 14q+ is necessary for the development of plasma cell leukemia. The actuarial survival curves gave no evidence for major prognostic significance of the demonstration of an abnormal cell clone. Trisomy for 1q21-1q3 may be a bad prognostic sign. The results are discussed with special reference to the aberrations in acute nonlymphocytic leukemia as reported earlier in a series of 88 cases from this laboratory.
Referência(s)