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Therapies with potential toxicity of neuro-ophthalmic interest

2003; Lippincott Williams & Wilkins; Volume: 14; Issue: 6 Linguagem: Inglês

10.1097/00055735-200312000-00004

1531-7021

Joseph D. Iuorno, Kevin P. Kolostyak, Luis J. Mejico,

Epilepsy research and treatment

Several therapies have potential neuro-ophthalmic or ophthalmic complications. We reviewed the recent literature for relevant therapies that affect ocular function. In this review, we discuss a variety of toxic effects of antiepileptic drugs, endocrine drugs, and miscellaneous therapies (intravitreal silicone oil and TNF-alpha inhibitors).The pathogenesis of these side effects is quite heterogeneous affecting visual sensory function at the levels of the ciliary body, retina, optic nerve and chiasm, and central visual pathways.Appropriate management requires prompt recognition of these associations. Practitioners should be familiar with these neuro-ophthalmic manifestations because they may present in the course of daily practice.